منابع مشابه
Hox collinearity - a new perspective.
Hox collinearity is a spectacular phenomenon that has excited life scientists since its discovery in 1978. Two mechanisms have been proposed to explain the spatially sequential pattern of Hox gene expression in animal embryonic development: interactions among Hox genes, or the progressive opening of chromatin in the Hox clusters, from 3' to 5'. A review of the evidence across different species ...
متن کاملBiophysics Precedes Biochemistry In Hox Gene Collinearity
Background: Hox gene collinearity is a universal phenomenon most emphatically observed during the development of vertebrate embryos. The last decade or so, a series of genetic engineering experiments have been performed including Hox gene deletions, duplications or transpositions. These experiments are illuminating and helpful to understand the mechanisms responsible for Hox gene collinearity. ...
متن کاملPulling forces acting on Hox gene clusters cause expression collinearity.
The development of normal patterns along the primary and secondary vertebrate axes depends on the regularity of early Hox gene expression. During initial stages, these expression events form a sequential pattern of partially overlapping domains along the anteroposterior axis in coincidence with the 3' to 5' order of the genes in the Hox cluster (spatial collinearity). In addition, the genes are...
متن کاملEvolutionary Constraints Favor a Biophysical Model Explaining Hox Gene Collinearity
The Hox gene collinearity enigma has often been approached using models based on biomolecular mechanisms. The biophysical model is an alternative approach based on the hypothesis that collinearity is caused by physical forces pulling the Hox genes from a territory where they are inactive to a distinct spatial domain where they are activated in a step by step manner. Such Hox gene translocations...
متن کاملGenomic evolution of Hox gene clusters.
The family of Hox genes, which number 4 to 48 per genome depending on the animal, control morphologies on the main body axis of nearly all metazoans. The conventional wisdom is that Hox genes are arranged in chromosomal clusters in colinear order with their expression patterns on the body axis. However, recent evidence has shown that Hox gene clusters are fragmented, reduced, or expanded in man...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2006
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2005.12.008